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Expression of C-kit and Platelet-Derived Growth Factor Receptors in Ovarian Granulosa Cell Tumors

¹ University of South Alabama
² University of Alabama at Birmingham

^* To whom correspondence should be addressed. E-mail: rocconi{at}usouthal.edu.

	Abstract

Objective. This study aimed at evaluating the expression of tyrosine kinase receptors c-kit, (platelet-derived growth factor receptor- (PDGFR-), and PDGFR- in ovarian granulosa cell tumors (GCTs). Study design. Primary ovarian GCT specimens were obtained for immunohistochemical staining. The expressions of c-kit, PDGFR-, and PDGFR- were analyzed and scored by a semi-quantitative (SQ) method. Normal ovarian tissue from the same patients’ specimens served as internal controls. Results. A total of 21 specimens were available for evaluation. C-kit was expressed in only 2 samples, whereas both PDGFR- and PDGFR- stained positive in 100% of tumors. PDGFR targets demonstrated strong positive expression in intensity and amount of tissue stained. Normal ovarian tissue demonstrated complete absence of staining for all 3 antibodies evaluated. Conclusions. The data demonstrated significant expression of PDGFR targets of imatinib mesylate in GCTs, whereas normal ovarian tissues had a complete absence of staining. This expression profile provides the rationale to investigate the role of imatinib mesylate in PDGFR-positive GCTs.

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