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First published on June 18, 2008, doi:10.1177/1933719108317300

Reproductive Sciences 2008;15:720.

A more recent version of this article appeared on September 1, 2008

Article

Angiogenic Growth Factors and Their Receptors in First-Trimester Human Decidua of Pregnancies Further Complicated by Preeclampsia or Fetal Growth Restriction

M. Plaisier, MD, PhD student1*, E. Streefland, MD2, P. Koolwijk, PhD3, V. W. M. van Hinsbergh, PhD3, F. M. Helmerhorst, MD1, and J. J. H. M. Erwich, MD, PhD2

1 Leiden University Medical Center
2 University Medical Center Groningen
3 VU University Medical Center

* To whom correspondence should be addressed. E-mail: m.plaisier{at}lumc.nl.


  Abstract
Disturbances in decidual and placental vascular development may play a role in the pathogenesis of pregnancy complications. This study focused on the role of angiogenic factors in the first trimester in the pathogenesis of preeclampsia (PE) and/or fetal growth restriction (FGR). First-trimester decidua was obtained during chorionic villous sampling.The expression of the angiogenic factors was determined by reverse transcriptase polymerase chain reaction and related to the pregnancy outcome. First-trimester decidua expressed all angiogenic factors.The differential expression of angiogenic factors appeared to be more prominent in FGR than in PE.These first-trimester samples provided a unique opportunity to obtain information regarding the onset of PE and FGR. First-trimester changes in angiogenic factor expression may well occur as a compensatory mechanism.This, in turn, may unintentionally set the stage for increased angiogenesis and altered decidual/placental vascular adaptation, which may be part of the pathogenesis of PE and/or FGR.


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