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First published on June 18, 2008
Reproductive Sciences 2008, doi:10.1177/1933719108316984

Article

Preeclampsia Risk and Angiotensinogen Polymorphisms M235T and AGT -217 in African American and Caucasian Women

Laura D. Jenkins, MD, MPH1*, Robert W. Powers, PhD2, Mary Cooper2, Marcia J. Gallaher2, Nina Markovic, PhD2, Robert Ferrell, PhD3, Roberta B. Ness, MD, MPH2, and James M. Roberts, MD4

1 University of Pittsburgh Medical Center
2 Magee-Womens Research Institute, University of Pittsburgh Medical Center
3 Pittsburgh Graduate School of Public Health
4 Magee-Womens Research Institute

* To whom correspondence should be addressed. E-mail: jenkinsld{at}upmc.edu.


  Abstract
Introduction: Genetic variants of the angiotensinogen gene have been linked to both hypertension and preeclampsia.The M235T polymorphism is more common in hypertension and preeclampsia in some populations. A polymorphism in the angiotensinogen basal promoter region of AGT -217 is more common in African Americans with hypertension.The authors investigated the frequency of M235T and AGT -217 in Caucasian and African American women with and without preeclampsia. Methods:The study was a nested case–control study of primiparous women with singleton pregnancies. Genomic DNA from preeclamptic and control subjects underwent polymerase chain reaction amplification and restriction digestion. Results:The M235T and AGT -217 polymorphisms were both more common in African American women; however, the variants were not more common in preeclampsia. Conclusion: The frequency of angiotensinogen polymorphisms M235T and AGT -217 is different by race; however, these polymorphisms are not associated with an increased risk of preeclampsia.


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