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Reduction of Brain Injury in Neonatal Hypoxic—Ischemic Rats by Intracerebroventricular Injection of Neural Stem/Progenitor Cells Together With Chondroitinase ABC

Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan, Department of Neonatology, Central Hospital, Aichi Human Service Center, Kasugai, Aichi, Japan

Keiko Nakanishi, MD, PhD

Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan

Masahiro Hayakawa, MD, PhD

Maternity and Perinatal Care Center, Nagoya University Hospital, Nagoya, Japan

Hiroko Kakizawa, MD, PhD

Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan, Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan

Akiko Saito, MD

Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan, Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan

Yoshiyuki Kuroda

Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan

Michiru Ida, PhD

Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan

Yoshihito Tokita, PhD

Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan

Sachiko Aono, PhD

Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan

Fumiko Matsui, PhD

Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan

Seiji Kojima, MD, PhD

Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan

Atsuhiko Oohira, PhD

Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan, atsu48{at}aichi-med-u.ac.jp

Perinatal hypoxia—ischemia (HI) remains a critical issue. Cell transplantation therapy could be a potent treatment for many neurodegenerative diseases, but limited works on this kind of therapy have been reported for perinatal HI. In this study, the therapeutic effect of transplantation with neural stem/ progenitor cells (NSPCs) and chondrotinase ABC (ChABC) in a neonatal HI rat model is evaluated. Histological studies showed that the unaffected area of the brain in animals treated with NSPCs together with ChABC was significantly larger than that in the animals treated with vehicle or NSPCs alone. The wet weight of the brain that received the combined treatment was also significantly higher than those of the vehicle and their individual treatments. These results indicate that intracerebroventricular injection of NSPCs with ChABC reduces brain injury in a rat neonatal HI model.

Key Words: Neonatal hypoxia—ischemia • neural stem/progenitor cells • chondroitin sulfate • chondroitinase ABC.

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