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This version was published on July 1, 2008
Reproductive Sciences, Vol. 15, No. 6, 572-583 (2008)
DOI: 10.1177/1933719107314060

ECG and Heart Rate Variability Changes in Preterm and Near-Term Fetal Lamb Following LPS Exposure

Sofia Blad, MSc

Perinatal Center, Department of Neuroscience and Physiology, sofia.blad{at}gu.se

Anna-Karin Welin, PhD, MD

Obstetrics and Gynecology

Ingemar Kjellmer, PhD, MD

Pediatrics, Sahlgrenska Academy, University of Gothenburg, Sweden

K.G. Rosén, PhD, MD

Neoventa Medical AB, Moelndal, Sweden

Carina Mallard, PhD

Perinatal Center, Department of Neuroscience and Physiology

The aim of this study is to evaluate the myocardial response in the preterm and near-term fetal lamb with infection. Chronically instrumented fetal lambs were exposed to lipopolysaccharide (LPS), and the fetal electrocardiogram (FECG) ST waveform was examined using STAN. Fetal heart rate variability (FHRV) was automatically analyzed by adapting a polynomial function to the RR sequence in the FECG. Preterm fetuses exposed to >90 ng/kg LPS died within 8 hours of LPS administration, a response not seen in near-term fetuses. In both surviving and nonsurviving preterm fetuses, cardiovascular responses were characterized by decreased arterial pressure, negative T waves, and tachycardia accompanied by an increase in FHRV. Similar changes were not observed in the near-term fetuses after LPS. The study shows that preterm lambs are more sensitive to LPS in terms of myocardial/cardiovascular response than the more mature fetuses are. High FHRV and negative ST waveform seem to characterize the LPS-induced stress response in preterm fetuses.

Key Words: Intrauterine infection • STAN • heart rate monitoring.


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